When Charlie Harris ends up in a coma, he leaves the Hope-Zion Hospital in chaos - and his fiancée and fellow surgeon, Alex Reid, in a state of shock. As the staff of Hope-Zion races to save lives, comatose Dr. Harris wanders the halls of Hope-Zee in "spirit" form, not sure if he's a ghost or a figment of his own imagination.
While searching for Charlie, Alex finds a caterer who was caught in the crossfire. Grace's mother asks for a priest. Dana consults with Cassie about a male stripper.
Alex and Charlie are confused about their relationship. Alex and Maggie disagree about a car crash survivor. Dana is forced to treat an injured motorcyclist. Zach bothers Maggie about dating.
Alex makes a promise to a young girl on her birthday. Maggie organizes a surprise party for Alex. Cassie is forced to confront her fear of infectious diseases.
Charlie tries to save the arm of a man thrown from a horse. Alex joins Manny off-site to help a runaway. A rival from Dev's past arrives at Hope Zion.
Alex tracks down the father of a patient who needs a liver transplant. The new CEO of Hope Zion is at odds with Dawn. Zach faces trials in the E.R.
Alex and Maggie ask Charlie for his opinion on a patient's treatment. Zach is persuaded by a patient while transitioning the ER to an urgent care facility.
Alex and Maggie deal with a tough lawyer after surgical complications with their cancer study patient. With the E.R. now an urgent care facility, Zach and his team aren't equipped to handle an accident victim.
Charlie and Manny treat a couple. Maggie evaluates the interns. Billy asks Maggie to be his mentor. Dawn tries to get her Chief of Surgery position back.
The doctors rally together to try to save an unknown man who was struck by a subway train. Randal delivers a warning about Charlie's gift. Dr. Sydney Katz returns to town.
Alex tries to distract herself from her grief. Charlie and Shahir try to track down Alex's brother. Alex treats a young girl with kidney failure. Maggie and Sydney treat a young woman with an STI.
While Charlie tries to save a young man's life, he is haunted by a mischievous spirit.
Alex and Maggie work together to deliver a baby. Charlie treats a magician.
Alex tries to help patient who hurt himself breaking into a house. A friend of Dr. Dev Sekara has been beaten by the police; a heart patient wishes to open an animal sanctuary.
Alex is challenged about the value of holistic medicine. Charlie's abilities are questioned. Two filmmakers go to Hope Zion Hospital.
The board questions the hospital staff about Charlie's behaviour. A patient convinces Alex to use new-age techniques. Shahir agrees to do an in-utero surgery.
Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.
Alex and Charlie put their wedding plans aside. Zach takes a special interest in a case. A coma patient who wakes up with no memory.
Alex and Charlie rush to the scene of a mass casualty accident involving a bus full of teenagers.