Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.
After being abducted by Katarina Rostova, Raymond "Red" Reddington finds himself alone in hostile territory unsure of who, if anyone, he can trust. With few leads to go on, Liz and the Task Force venture into unknown danger as they race to find him.
Liz, Dembe and the Task Force continue to search for Red. Red attempts to escape his abductors with help from a surprise ally, but discovers he is not Katarina Rostova's only target in her hunt for information.
Aram goes undercover to infiltrate a secret society of wealthy thrill-seekers, whose entertainment hinges upon spectacular acts of violence. Meanwhile, Red tries to negotiate with a former associate involved in the Townsend Directive, while Katarina Rostova takes steps to insinuate herself into Liz's life.
Cooper's moral compass is tested when an officer whom he served with as young man, long presumed to be dead, resurfaces as a POW.
Liz and the Task Force investigate an infamous assassin who has a long history of weaponizing diseases, but has now turned to even more insidious activities. Meanwhile, Red and Dembe travel to Cuba in search of a lead, and Aram considers a new relationship. Elizabeth Bogush guest stars.
Red alerts the FBI to the suspicious death of a scientist specializing in artificial intelligence research. Meanwhile, Francesca Campbell further entangles herself in Red's criminal activities
The Task Force investigates the unexplained disappearance and sudden re-emergence of a governor. Meanwhile, Red and Dembe surveil someone close to Katarina Rostova, as she inadvertently involves Agnes in an operation of her own.
Desperate for information about the whereabouts of a longtime friend, Red directs the Task Force to find a blacklister who specializes in untraceable money transfers. Meanwhile, Liz receives some disturbing news from her daughter Agnes.
Red and Liz investigate Orion Relocation Services, an organization that surreptitiously facilitates the disappearance and relocation of criminals. Meanwhile, Katarina delves into the memories of an old friend in order to get additional information about the Townsend Directive.
Red and the Task Force pay a visit to a former blacklister, as an explosive confrontation leads Liz to make a critical choice