Vanessa Helsing, the daughter of famous vampire hunter and Dracula nemesis Abraham Van Helsing is resurrected five years in the future to find out that vampires have taken over the world and that she possesses unique power over them. She is humanity’s last hope to lead an offensive to take back what has been lost.
After waking in the Dark Realm, Jack is sent through a portal with only the words to guide her.
Jack joins forces with her once-sworn enemy, who reveals a dangerous weapon that will help the Van Helsing's kill the Dark One, but the consequences of using this weapon are dire.
Jack faces off against the Dark One with a new ally whose allegiances may not be trusted.
Axel and Julius awaken in the Sunshine Unit, where a familiar face reveals the truth about their injuries. At Fort Collins, Violet and Ivory must convince their captors they are not traitors.
Violet and Ivory are on the run from Fort Collins with the now vulnerable Sisterhood. Violet must risk everything to keep the amulet out of The Dark One's hands.
While on the Van Helsing trail, Axel and Julius meet Nina — an important figure from Julius' past, but is she as innocent as he remembers?
As Axel and Julius continue their search for the Van Helsings, Violet and Ivory try to decipher a new clue all the while staying one step ahead of The Dark One.
Axel, Violet, Jack and Ivory are on their way to D.C. when an attack from the military leads them to take cover in an abandoned mine. But the mine may not be as safe as they think.
Vanessa wills Axel into The Dark Realm where they both discover secrets of their past that may help them in the future.
Axel and Violet inadvertently save an important figure from America's past who could help them turn the tide in their fight against The Dark One.
As The Dark One yearns to release her full power upon the real world, her plans are interrupted by a strange visitor to the White House.
Vanessa, Axel, Jack, Violet and Ivory finally reunite in the real world and begin their plan to take down The Dark One.
The team finally faces the Dark One in a treacherous battle that will affect the fate of humanity.