The Big Bang Theory is centered on five characters living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's equally geeky and socially awkward friends and co-workers, mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense.
Sheldon and Amy's honeymoon runs aground in New York, while Penny and Leonard discover they are uncomfortably similar to Amy's parents, Mr. and Mrs. Fowler. Also, Koothrappali insults physicist Neil deGrasse Tyson and starts a Twitter war.
Sheldon and Amy drive themselves crazy trying to figure out what "perfect gift" Leonard and Penny gave them for their wedding. Also, Koothrappali decides he wants to settle down and asks his father to arrange a marriage for him.
The Wolowitzes' life gets complicated when Stuart starts bringing his new girlfriend home. Also, Penny and Leonard talk about starting a family while Koothrappali explores an arranged marriage.
When Sheldon won't tell anyone why he's never mentioned Tam, his childhood best friend, Leonard takes matters into his own hands. Also, Bernadette and Penny take out Raj’s fiancée, Anu, for dinner to get the skinny on her.
When Amy doesn’t have time to work on super-asymmetry, Sheldon goes to great lengths to ensure she’s available to work with him even it if means accidentally sabotaging her career in the process. Also, Koothrappali doesn’t want Wolowitz to join him in hosting a show at the planetarium.