Sick, twisted, politically incorrect and Freakin' Sweet animated series featuring the adventures of the dysfunctional Griffin family. Bumbling Peter and long-suffering Lois have three kids. Stewie (a brilliant but sadistic baby bent on killing his mother and taking over the world), Meg (the oldest, and is the most unpopular girl in town) and Chris (the middle kid, he's not very bright but has a passion for movies). The final member of the family is Brian - a talking dog and much more than a pet, he keeps Stewie in check whilst sipping Martinis and sorting through his own life issues.
Stewie finally says his first word, and it's a swear. When Lois is shunned by the other moms, she tries to figure out where Stewie could have possibly learned it.
Stewie "breaks up with" Rupert after learning that he used to belong to Chris. Unable to get over his feelings of betrayal, Stewie decides to take action.
When Peter injures himself and a family of squirrels in a chainsaw accident, Chris and Stewie take in one of the injured rodents to nurse it back to health. Meanwhile, a chiropractor fixes Peter's injury by realigning his spine - and restoring him to his "true height" of 6'5".
Peter and Lois accidentally set up a cutaway gag together, which somehow transports them into the cutaway itself.
When Joe asks Peter to be the godfather to his daughter, Peter commits to his mistaken interpretation of the role so much that he becomes a real gangster.
Meg plans her wedding to an unexpected Quahog resident. Meanwhile, Peter finds a new vest and on one of many adventures fitting for his new attire, his arms are torn off and he is left with tiny hands that have yet to grow back.
Lois and Peter are divided by differing views on who the next Mayor of Quahog should be. Upset at Lois' first choice, Peter seeks out the late Mayor Adam West's cousin, Wild Wild West.
Brian's new job as a journalist leads him to uncover that Pawtucket Pat, Quahog's hero and brewery founder, took part in racist actions against Native Americans; the town becomes divided on whether or not to remove the statue that commemorates him
When the family fails to help Lois with the Christmas shopping, she walks out on the family and the Griffins must try to save Christmas on their own.
When Peter makes it through a bad flu season without getting sick, the hospital asks him to volunteer as a nurse, but he finds himself at a crossroads when his mortal enemy, The Giant Chicken, is admitted to the ER. Meanwhile, Brian receives his genetic test results and learns he is part cat, causing him to have an identity crisis.
Brian bonds with his new girlfriend's son; Peter, Quagmire and Cleveland take a joy ride in Joe's new classic corvette.
After attending a baseball game, Peter and Chris are inspired to start a memorabilia business. Meanwhile, Stewie tries to combat aging by getting plastic surgery, but ends up taking it too far.
Stewie designs a "Terminator" Peter robot to destroy Lois for trying to feed him broccoli, but when things don't go according to plan, Stewie and Brian must go on a Terminator-esque mission to save Stewie's life.
Stewie gets a mail order bride from Ukraine and experiences domestic life. Meanwhile, Peter and Chris become addicted to free hotel breakfast buffets.