Sick, twisted, politically incorrect and Freakin' Sweet animated series featuring the adventures of the dysfunctional Griffin family. Bumbling Peter and long-suffering Lois have three kids. Stewie (a brilliant but sadistic baby bent on killing his mother and taking over the world), Meg (the oldest, and is the most unpopular girl in town) and Chris (the middle kid, he's not very bright but has a passion for movies). The final member of the family is Brian - a talking dog and much more than a pet, he keeps Stewie in check whilst sipping Martinis and sorting through his own life issues.
Meg agrees to be Bruce and Jeffery’s surrogate causing a pregnant Meg to annoy her family. But, when the couple fails to pick up the baby, the Griffins must take care of their new family.
With the brewery under construction, Lois implores Peter to take a new job, but grows irate when he begins work at the grocery store. Meanwhile, armed with his police stories, Joe and Brian team up to write their own true crime novel.
When Peter loses the Griffins' home in a reverse mortgage, he and Mayor West travel to confront the man advertising the scheme, Tom Selleck. Meanwhile, Stewie and Brian open a booth at the flea market, leading to a rivalry with Bruce.
Peter and Lois vacation in Florida, only to discover they've rented a condo in a retirement community. Back at home, Brian helps Stewie take his first shower.
Peter is emasculated when, on their anniversary, he abandons Lois amidst a shark attack. Meanwhile, Stewie finds a mini fridge and lives the dorm lifestyle.
Stewie tries to civilize his half-brother, Boston Stewie, so that he may be adopted. Meanwhile, Meg and Chris start a venture in which people online pay Chris to sit on and smash cupcakes.
Winner of a Snapple contest, Lois uses her winnings to take Meg on a tropical vacation. Flaunting their wealth, the two are kidnapped. Meanwhile, Stewie and Brian undergo "friendship therapy."
Meg discovers her tears produce delicious cookies, and her, along with her siblings, enjoy a profit until the success makes her too happy to cry. Meanwhile, Peter and the guys launch a "male talk show."
Lois decides to sell the family's television to help pay for Christmas presents, but when Kevin James gets upset over losing Peter as a viewer, he apparates into the Griffin house.