Three very different women find themselves drawn together by a mysterious man who unleashes unique powers in each of them, and this small New England town will never be the same.
Three women residents of the New England town of Eastwick each make a wish on a coin, summoning a mysterious man named Darryl Van Horne into their town. Strange things occur upon his arrival and local historian Bun predicts ominous events in the horizon.
As Eastwick prepares for its annual fall HarvestFest, Joanna, Kat and Roxie's lives continue to take a turn for the strange. Distracted by distressing psychic visions of her new neighbor, Jamie, Roxie struggles to protect Mia from harassment by her ex-boyfriend, Gus. As Kat gains the courage to end her own toxic relationship - her marriage to Raymond -- he's back in their home to recuperate from being struck by lightning. And while Joanna worries that Will's romantic attentions are only due to her hypnotic power, she and Penny embark on a perilous mission to uncover Darryl Van Horne's true identity. Joanna finds Milton Philmont, a retired Gazette reporter who years ago wrote about the death of a man named Sebastian Hart - a man who looks uncannily like a young Darryl Van Horne. Armed with an old photo of Hart with three beautiful women, she and Penny seek answers from the eccentric and reclusive Eleanor Rougement.
Haunted by the ghost of her daughter's ex-boyfriend, Roxie questions her sanity and turns to a local psychic for help. Declining Darryl's offer of a high-powered - and high-priced - divorce attorney, Kat decides to give Raymond another chance, but is she only delaying the inevitable? Joanna's quest to find the truth about Darryl leads her to a new and different scandal, and then she realizes her discovery was no accident. Meanwhile, Roxie's daughter, Mia, reluctantly attends her boyfriend's memorial, and though Bun has lost her memory, her mind is consumed with a mysterious symbol.
With a little urging from Darryl, Roxie decides to learn more about her mysterious new neighbor, Jamie (Jack Huston) - and she ends up making a magical discovery. Terrified by Raymond's threat to take their children, Kat decides to go on the offensive and finally accepts the help of Darryl's divorce lawyer. And just as Joanna's long-awaited date with Will approaches, Morgan, her ex-fiance, arrives in town, tempting her to find out what went wrong between them
Kat fulfills a fantasy; Mia and Roxie find themselves in an embarrassing predicament; Joanna's rush to print a story gets her into trouble.
In Eastwick, Halloween is the most important holiday of the year, when the town embraces its heritage with a good old-fashioned witch burning. Haunted by visions of a funeral, Roxie races to save those she loves from peril - but can she change fate? Wrestling with her feelings for Will, Kat tries to help Joanna win him back, but only manages to drive her away. And, devastated after losing her job and her man, Joanna discovers things can always be worse.
After Chad visits her one last time in a dream, a grieving Roxie resolves to fulfill his last wish -- if she can figure out what it is. Hounded by Max, her replacement at the Gazette, about her kidnapping ordeal, Joanna grapples with her own lingering questions while dodging his. And Kat, startled by a newfound ability, realizes that Bun's old friend Eleanor Rougement, may have answers for both of them.
Darryl organizes an art show of Roxie's work at his mansion; Joanna tries to use her power to get her life back in order; Kat doesn't know how to move on.
Roxie learns of a new ability as her mother Edie comes to visit. Darryl tries to persuade Kat to use her healing powers to save Greta. Joanna's rivalry with Max escalates while Jamie finds allies in Eleanor and Bun in eliminating Van Horne.
After Jamie reveals to Roxie that Darryl is his father, she sets about having a dinner party where father and son can bond. But Jamie has a secret, darker plan for the evening. Meanwhile Kat embraces her newfound power by healing every patient she comes into contact with, but her compassion leads to drastic physical consequences. And Max asks a reluctant Joanna to help him crack a famous unsolved Eastwick murder, but their snooping leads them to a perilous situation with Eleanor.
Roxie’s nightmares come true as she struggles to escape from Jamie, and Joanna and Max fight for their lives.