Ray Barone a successful sportswriter living on Long Island with his wife, Debra, daughter, Ally, and twin sons, Geoffrey and Michael. That's the good news. The bad news? Ray's meddling parents, Frank and Marie, live directly across the street and embrace the motto "Su casa es mi casa," infiltrating their son's home to an extent unparalleled in television history.
Frank and Marie return from a trip down to a retirement home in New Jersey when they tell the family that they plan on moving there. Everyone, besides Frank and Marie, is overjoyed fro hearing the news. Marie and Frank sell their own house to Robert and Amy for $26,000. On they day of their moving, however, Debra reveals some mixed feelings about their moving and doesn't feel right about it.
When Ray and Debra visit Fank and Marie's condo, they learn that the owners are going to kick them out. Marie and Frank move out. Robert and Amy are upset, but they let Frank and Marie live with them.
When Debra and Marie have a big fight, Ray is struck with worry when he thinks Debra's anger will cause her to forget about their sex that night. But, it is the opposite when that anger causes a more intense night with sex. Ray really begins to enjoy it and realizes that the angrier Debra gets at Marie, the better sex they have. When Marie comes over to apologize, Ray makes up a chain of lies to both Marie and Debra so it doesn't ruin his plans.
Ray is elected to tell Debra that members of the P.T.A. have problems with the way she dresses.
After Ally comes home with an ""F"" on her report card, Debra feels she is not paying enough attention. Ray, however, feels it might be the teacher. After a small meeting, Ray goes on how Debra didn't do anything to stick up for Ally and how you should always stick up for your kids. Frank and Marie could relate to Ray's disobediance when he was in high school. But Debra finds out that Ally has a crush on Tommy Sanders, a boy in her class. When Debra confronts the teacher with this, it turns out that the teacher is a mean old bat that doesn't understand the trials kids go through.
The women pressure Ray and Frank to accompany Robert to one of his therapy sessions. Instead, they go out to the track, and then put on an act in front of the wives. However, even though they skip the therapy sessions, the three unwittingly get closer.
Debra invites her divorced parents, Warren and Lois, to the family Thanksgiving. When Ray walks in on the two making love, he and Debra assume that they are getting back together. Later on, Warren and Lois inform Debra otherwise and an unprecedented turn of events shocks everyone.
Ray becomes jealous when Marie starts treating Robert better than him. Ray finds out that Marie gave Robert a ""gift basket"" full of lotions, massage oil, candles, etc. Ray deduces Marie is just manipulating Robert by giving him all this, so it will put him and Amy 'into the mood'. She does this with the intention of eventually having new grandchildren. Robert sees this as wrong, and actually puts him out of the mood with Amy, not able to get Marie out of his head.
Amy's parents ask Ray to give their son, Peter, some tips on dating. Later, Debra throws a cocktail party and invites some single women to meet Peter, but Ray isn't thrilled with the guest list.
Debra complains to Raymond about leaving things around the house. Later on, when Raymond receives a personal letter from his idol, Muhammad Ali, he remembers what Debra told him, so he puts it away in a drawer. Unfortunately, when Debra later looks for a coupon in the same drawer, she's so put off by how much 'junk' is in there, she indiscriminately dumps most of its contents into the trash - and then dumps the trash into a garbage truck just as it arrives. When Debra realizes her mistake, she goes to Marie, desperate for help. Marie takes the blame, but Debra soon finds out that Marie, as always, has ulterior motives.
Ray accidentally insults the twins' new friend and the faux pas quickly spirals out of contral when he repeats it to the boy's dad.
Marie is astounded when Franks puts salt on her homemade lasagna, leading her to believe that she's lost her tough in the kitchen. However, Ray and Robert discover that the problem is Frank, who has lost his sense of taste. They believe it's a side-effect from some potency medication Frank is taking, but Frank doesn't want to give it up, and he doesn't want anyone to know he's taking it, especially Marie.
Ray tells Robert that Amy talks too much after she chats with Ray for over an hour while he tries to watch a basketball game on TV. Of course, Robert tells Amy, which leads to a heated confrontation between ""Lady Chatterly"" and her insensitive brother-in-law.
Ray's latest manipulative plan involves constantly turning down Debra in the bedroom.
Robert discovers Pat smoking and she pleads for him not to tell. Later, when Amy smells smoke on Robert, she thinks Robert smokes. Frank, Marie, Peter, Hank and Amy all think Robert smokes. Robert gets yelled at, and Pat doesn't tell the truth or back him up. The next day, Robert tells Raymond and Debra about Pat, and the family comes over. There is a bitter argument and then Ray and/or Debra yells out that Pat smokes. She confesses and tells the truth. There is another argument and Peter confesses something, then Hank, then Ray, then Debra. It ends with Frank and Marie telling them that they are weird and that they shouldn't do the stuff they are doing.
Ray fears getting his adenoids removed, but Debra convinces him to go through with the surgery. At the hospital, while Marie is in the bathroom, the nurse says that Ray isn't waking up from the anesthesia and everyone fears he may die. Fortunately, thirty seconds later, the doctor comes out and says he's just fine. Everyone agrees not to tell Ray or Marie about it; however, Frank ends up telling Marie who rushes over to smother Ray with kisses. Ray finds out about it and begins acting weird as if he thinks he really is going to die. After a couple minutes, he gets out of it. The show closes with the entire family sitting around the table eating and arguing, just like the Barones always have in the past nine years.