A look into American politics, revolving around former Senator Selina Meyer who finds being Vice President of the United States is nothing like she expected and everything everyone ever warned her about.
Selina evaluates her past and present campaigns. Jonah's personal life sparks interest among the press. Amy makes an important decision.
At an Aspen retreat for rich donors, Selina deals with potential adversaries and allies. Amy's behavior raises Gary's suspicions.
In the run-up to the first debate, Selina makes a novel campaign proposal. Comments by Jonah create blowback. Dan and Amy take a road trip.
Selina and team head to South Carolina, where she seeks an endorsement from a key leader. Gary gets a long-awaited promotion, while Marjorie excels in her new role.
Facing increased scrutiny heading into Super Tuesday, Selina visits Mike to deflect attention from Andrew's legal troubles. Jonah and Amy ramp up their anti-Selina campaign rhetoric. Dan attempts to exploit Richard.
Selina tries to arrange a meeting via her Finnish contact Minna. Gary helps Catherine plan a big event. Jonah and Amy push an anti-vax message in Pennsylvania. Mike finds a new home. Richard may have an enemy.
The nominating fight between Selina and her rivals reaches its climax, as their race comes to a historic finish. Series finale.