Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.
In the aftermath of a shooting, the team must work to find Alice Sands (Annabeth Gish) and bring her to justice before she destroys Jane's life.
While the entire Boston Police Department searches for Alice Sands, the team investigates a car crash that isn't all it seems. In the midst of this, a new romance blossoms.
The team works on behalf of the dead - and the undead - after a murder at a zombie convention. Angela decides to pursue her GED after revealing that she never graduated from high school.
When a mailman is killed, the team must work with a brash, eccentric postal inspector, who believes the mailman's murder is part of a larger conspiracy. Maura continues to struggle with the ramifications of her injury, and Angela intervenes when she discovers Korsak has gotten Kiki a terrible birthday present.
When a wealthy woman is found dead at the bottom of her stairs, we realize that this was no ordinary slip-and-fall accident. The team is pressed into a game of cat and mouse with a clever killer determined to get away with the perfect crime. Plus, when Maura decides to undergo minor surgery, the surprising part of her healing will be reconnecting with Hope.
Jane and Maura must unravel an old ghost story to solve a double murder at a hospital; Angela convinces Frankie to stop avoiding Kent.
When a bicyclist appears to spontaneously combust, Maura proves his death is actually a murder; Jane is invited to teach a class of FBI recruits at Quantico.
Jane goes under cover in a county jail to draw out a killer who committed a brutal murder.
On the morning that Jane is supposed to testify in a murder trial, she discovers that a key piece of evidence has been stolen; Frankie decides to learn some magic tricks to impress Nina.
When a forensic accountant is gunned down, Jane and Maura are drawn into a Ponzi scheme. But the biggest surprise is Jane's discovery that her prime suspect is someone from Maura's past. Jane also makes a life-changing career decision.
A mortician's body is discovered in one of his caskets, leading the team into the world of embalming, interment and serial murder. Tommy Rizzoli visits with his son and considers returning to Boston. Jane's loved ones react to her news.
Jane and Maura work to solve two murders -- one from the past and one present day -- that have deep personal connections for Korsak. Jane gets a surprise visit that might lead to romance, and Maura gets upsetting feedback on her novel.
The facts don't add up when a dead man is found handcuffed in his home. As the Bon Voyage party approaches, everyone makes a video to say goodbye. In the series finale, everyone says farewell and plans for their next adventure.