The story of the legalization and subsequent rise of the porn industry in New York’s Times Square from the early ’70s through the mid ’80s, exploring the rough-and-tumble world that existed there until the rise of HIV, the violence of the cocaine epidemic and the renewed real estate market ended the bawdy turbulence of the area.
On the eve of 1985, a worn-out Vincent reconnects with his ex-wife, Andrea, as his open relationship with Abby grows more distant. Despite becoming a family man, Frankie continues his risky side hustles. With the newly dominant VHS format shaking up their industry, Candy and Harvey travel to Las Vegas for an adult film convention. Now a bartender at the Hi-Hat, Loretta becomes an active member of Women Against Pornography.
Frankie takes his amateur porn business to the next level and ends up in a confrontation with Rudy, who pushes Vincent to up his profits. Candy brainstorms a new film based on the experiences of her fellow sex workers and finds that her new beau Hank is not shaken by her past. Abby and Loretta take care of Shay when she shows up to the Hi-Hat in bad shape.
Abby befriends a graffiti artist named Pilar and takes a surprising trip downtown. Candy sets a firm line with Hank when it comes to money. Todd re-examines his priorities and asks for Paul's support. Melissa is forced to face her past.
Lori returns to New York for an audition and runs into some familiar faces. Candy speaks to her critics at a Women Against Pornography meeting. Alston takes a drastic step to deliver for Goldman. Vincent and Frankie celebrate an eventful birthday.
A distraught Vincent follows a lead down a dangerous path. Paul reaches out to Tod's parents. Candy battles Harvey over her latest script. Lori hits the feature dancing circuit. Abby reflects on her choices. Bobby does right by Black Frankie. Alston defends the plan to clean up Midtown. Gene reckons with his conflicted personal life.
In the wake of a personal loss, Candy finds the emotional core of her latest movie. Abby confronts Vincent after she makes an alarming discovery. Paul turns to activism as the AIDS epidemic continues to ravage New York's gay community.
A struggling Lori turns to Candy for help before revisiting The Deuce. Candy makes a surprising deal to secure funding for her film. Abby takes a stand against the latest phase of Midtown redevelopment. Tommy explains the new world order to Vincent.
Big changes come to The Deuce as Gene sees opportunity in the city's public health crisis. Vincent looks to get out from under the mob's thumb and makes peace with Abby. Candy makes a critical choice in her relationship with Hank. Series finale.