Sitcom following a successful African-American couple, George and Louise “Weezyö Jefferson as they “move on up” from working-class Queens to a ritzy Manhattan apartment. A spin-off of All in the Family.
The Help Center is having a blood drive and Louise tries to get George to give some. However, a leery George pays Ralph to give blood in his name. But when, the blood saves the life of Mrs. Whittendale, her husband decides to pay George back for his good deed and of course Ralph wants in on the ""payback.""
The snobby socialite that beat Louise out of a Volunteer of the Year award is back and brags about how her grandson is going to win a piano recital. This leads Louise to enter her granddaughter, Jessica in the recital with the intent of beating the snobby competition.
Louise and Florence have the perfect plan to get the best of George. They've got the hidden video show, Boobles, Bangles and Booboos coming over on the pretense of an interview for George. However, Louise and George begin to doubt the validity of them when the apartment is robbed.
Louise is running for tenant council president and is sure she's going to win, that is until she discovers someone is running against her, George.
George, Louise, Tom and Helen go out to a big charity ball where Florence's favorite soap star is scheduled to make an appearance. However, Florence is left behind because tickets for the event where sold out. This leads Florence to daydream a ""Cinderella"" story of ending up with a prince charming.
Louise is all excited that for once George has remembered her birthday after she sees him sneaking around with party favors. However, George, who overhears Helen and Louise, realizes that he has forgotten her birthday and scrambles to buy her a gift before it's to late.
Florence is all excited since her and her church choir are going to Ohio for a competition. However, Florence loses her faith in God when the Reverend steals the money they needed to enter the competition.
After catching vandals trying to break into his store, George and Louise stake it out and are surprised when two young kids break in. George wants to call the police but Louise bets George that if she can't turn them around, he won't have to give her $2,000 to save the Help Center's children's counseling program.
Needing some quick cash to fly to a family get together, Florence accompanies George and Louise to Atlantic City where Florence is struck by gambling fever. Meanwhile, Louise is determined to see some celebrities unknown to her she is running in to them everywhere she turns.
George undergoes constant insults and humiliation after dropping Reggie Jackson's home run hit at a baseball game. This leads Louise to make attempts to boost his floundering self-esteem.
When George, Louise and Helen are busy for an evening, an ignored Tom gets all the attention he could want from the sister of Mr. Bentley's girlfriend. This leads Tom to daydream what it would be like to get all the attention all the time from five Playboy Playmates.
Lionel and Jenny return to New York after a trip to Japan and they have a very important announcement. This leads Louise, George, Tom and Helen to assume that Jenny is pregnant. However, no one is prepared for their real announcement. They've decided to get a divorce.
After hearing the news of the divorce, George and Louise get into a big fight with Tom and Helen and the fight continues all the way through Family Night at Jessica's school. The constant bickering leads Jessica to run out of the school and onto the streets of New York.
George's assistant, Clark doesn't have a date for the prom and Florence agrees to go with him. However, once there Florence runs into the man whom she wanted to go to her prom with but he never asked her.
When Charlie goes out of town for the weekend, Louise agrees to be the bartender for a party he had previously booked. However, Louise quickly finds herself in over her head when the party is for a reunion of a biker gang.
Tom is up for a promotion to president of Pelham Publishing and he's disappointed when it looks as if he's not going to get it. However, when he does get promoted, he finds the responsibility too overwhelming and considers resigning.
George and Louise's anniversary party comes to a screeching halt when they learn that Charlie, the bartender, has a drinking problem, which caused his separation from his wife.
George is in yet another advertising war with Cunningham Cleaners and each has vowed to out promote one another. However, the festivities go to far leading to Cunningham's death and leaving George to deal with his vengeful widow.
Louise is up in arms over the new "young" tenant whose just moved into 12C. The young woman's constant partying prompts Louise to call a tenants meeting but ends with Louise discovering a little bit about age when the tenants accuse her of being an "old" stick in the mud.
When Louise and Helen go to a spa for the weekend, they leave behind two bored husbands. To pass the time, George and Tom decide to break a record and the record they choose is how many times they can go up and down on the elevator.
Louise is all excited about the completion of her painting in art class. However, everyone who views her painting lies about how they really feel about it, leading Louise to believe she has created a masterpiece and she later decides to put on an art show.
Florence is tired of being alone and decides to place an ad in a personals column. However, the one response she gets is from someone who you would least expect, Mr. Bentley.
Louise and Helen need quick cash to save their Disabled Youth Services program down at the Help Center. To raise money, they decide to put on a talent show, while George thinks it'll be a great way to promote his business.
George is eyeing to win the Dry Cleaner of the Year award but finds he's short on the community service portion. This leads him to take over as ""nest mother"" of Jessica's Red Robin troop where he gives the girls irresponsible tips on how to sell candy.