A preacher sets out on a mission to make the almighty himself confess his sin of abandoning the world. With his best friend Cassidy, an alcoholic Irish vampire, his love Tulip, a red blooded gun towing Texan, and the power of genesis, an unholy child born from an angel and a devil, Jesse gives up everything to set the world straight with its creator.
Visions of the apocalypse plague Jesse as he and Tulip get ready to strike Masada, where Cassidy is trapped, but Grail and Starr are ready for their assault; Jesse tries to find an unusual rock formation; Tulip attempts to rescue Cassidy.
Jesse looks for God as the apocalypse looms; Tulip attempts to save Cassidy.
Tulip gets in too deep in Masada; Cassidy reflects on a lost life; the Saint closes in on Jesse.
Tulip forges an unexpected alliance to save Cassidy; Jesse finds himself stranded.
Tulip reunites with Cassidy and Eugene finds Jesse; the Grail's agenda threatens to unwind.
Tulip and Cass track Jesse and the Saint of Killers, while Starr searches for the missing messiah.
Tulip and Cass tear after God; an old friend presents Jesse with an unique opportunity.
Tulip and Cass struggle to keep Humperdoo hidden from the Grail, while Jesse remains MIA.
Jesse, Tulip and Cassidy mount one final assault on Masada as the Apocalypse Revue begins.
The fate of the world is decided as the long journey of a preacher and his friends comes to an end.