Saber Rider recalls how he, April, Colt and Fireball met and became the dynamic frontier fighting team: Saber Rider and the Star Sheriffs. Saber Rider arrives on Planet Yuma for his assignment to the special project, Ramrod, which is being led by April. He discovers that the Outrider, Vanquo, is plotting to undermine Ramrod, and, with the help of Fireball and Colt, who are on Yuma pursuing their own interests, Saber Rider defeats the Outriders and their gigantic battle machine, Renegade. With April's encouragement, the group decides to stay together to help tame the new frontier.
When the Star Sheriffs arrive to investigate a destroyed Cavalry Command base, they are attacked by Outriders. One of the Star Sheriffs must go on a maverick mission to defeat them. Using a trick coin, Colt wins the toss against Saber Rider and flies off to battle the enemy, who trap him in a canyon. But, help comes from an unlikely source: a little iguana that Colt has befriended. With the iguana's help, Colt escapes and joins the other Star Sheriffs in defeating the Outriders.
Jesse Blue hits on April, but she rebuffs him and General Whitehawk intervenes.
Colt takes an iguana as a pet when the Outriders attack a Dallas settlement.
A renegade unit forms and plans an attack against the Star Sheriffs.
A circus comes to town.
The team are ambushed during a distress call on Planet Dakota.
A business tycoon is investigated for working with the Outriders and Saber, Colt and Fireball go undercover.
An explosive is planted at a peace summit and Outrider agents turn on someone who is helping them.
A Rainbow Planet is invaded as Outriders plant devices in the ears of its citizens.
Fireball meets a female pilot who helps the team approach the Outrider's ship.
Common traits surface between the humans and Outriders as Cavalry Command plans a rescue mission for Commander Eagle.
The rescue mission begins.
Commander Eagle returns and shares what he learned in captivity. Later: Jesse Blue arrives on planet Yuma as an ambassador of Nemesis.
The peace treaty is signed.
Suspensions are levied on Saber Rider; April; Colt; and Fireball.
The team try to end the war by attacking computers in the Outriders' orbital station, but Jesse Blue throws a wrench into their plan.