James "Jimmy" Chance is a clueless 24-year-old who impregnates a serial killer during a one-night-stand. Earning custody of his daughter after the mother is sentenced to death, Jimmy relies on his oddball but well-intentioned family for support in raising the child.
Burt and Virginia decide to investigate a when strange man keeps popping up in the Chances' lives. Maw Maw reveals a secret about Virginia's past.
Burt and Virginia introduce Natesville to a new bartering system called "Burt Bucks," that looks an awful lot like a pyramid scheme. Jimmy questions his masculinity after Sabrina saves his life.
When Sabrina learns Jimmy never went on a family vacation as a kid, she decides to take Hope on a trip and prove to Burt and Virginia that family vacations aren't necessarily stressful.
Virginia is thrilled when the doctor prescribes new glasses, until her new crystal-clear vision allows her to see every tiny imperfection around the house.
Howdy's gets business innovator Maxine as its new owner, and all employees must come up with a big idea to change the store.
Sabrina wants to officially adopt Hope as her own, but the official adoption process doesn't give her the "Motherhood Moment" for which she was hoping.
Burt and Virginia get new back-fence neighbors, and Burt is convinced that there is something suspicious about them.
Virginia and Burt fear that Jimmy and Sabrina's marriage has lost its spark, so they use their own relationship experiences to try and shake things up.
Burt wants to be elected the interim Mayor of Natesville so that Virginia will have the honor of plugging in the town Christmas tree. But being mayor turns Burt into a Grinch.
Burt and Virginia go undercover to expose a corporate scandal that is killing all the bees in Natesville.
Maw Maw accidentally calls a wrong number in her contact book, bringing Virginia's cousin, Delilah, back to town. When the two rivals fight nonstop, Maw Maw threatens to give everything in her will to the granddaughter who can act the most civil. Meanwhile, Jimmy and Sabrina have trouble finding a babysitter for Hope.
Virginia offers to give Sabrina some much-needed cooking lessons. But when Jimmy proclaims that his wife's casserole is better than his mom's, it brings out Virginia's competitive side and she enters herself and her daughter-in-law in the Hot Dish competition. To ease the tension, Burt also invites his mother to enter the contest.
In trying to help Barney and Maxine's budding relationship, Burt and Virginia wind up getting in a fight. Meanwhile, Jimmy and Sabrina decide to start fencing in order to relieve some of the tension in their relationship.
"Groce-letes" from around the world descend on Natesville for the International Grocery Games, where competitors battle for supremacy in the aisles of Howdy's. But, when the American delegation is embroiled in a shocking performance-enhancing drug scandal, the Howdy's team, along with Burt and Virginia, must pick up the torch for the Stars & Stripes.
Virginia thinks that Burt is getting her an expensive gift for their 25th anniversary. So she decides to take him to a dude ranch that is run by a crazy cowboy. But Burt isn't able to enjoy himself, because of a secret he is keeping from Virginia.
Maw Maw has found a new love, Hubert, who encourages her to engage in some reckless activity. When Virginia finds herself scolding Maw Maw, she fears she's become a lame adult and wants Burt to do more risk-taking activities with her. Jimmy and Sabrina follow suit when they find themselves spying on their own babysitter.
Burt and Virginia are in desperate need of a vacation and, at Barney's suggestion, head to a resort for a little R&R. But the "resort" turns out to be a different kind of place than they were hoping for. Meanwhile, Jimmy and Sabrina decide they want to have a baby.
Virginia's boss Louise begins grooming her for the role of regional sales manager. But when Virginia sees what her boss' job is really like, she has second thoughts. Meanwhile, Jimmy and Sabrina are worried about Hope's lack of compassion when she feels no sadness over the death of her pet fish, and Burt and Virginia perform at the Natesville Telethon.
Virginia stops believing in magical things, but second guesses herself when a ghost appears in their house. When Burt discovers that Jim Hughes has secretly been living in their house's bomb shelter, Burt and Jim play along with Virginia's antics in order to make her believe in the paranormal again. Meanwhile, Burt and Virginia learn some news about Jim that scares them straight.
When Virginia and Burt realize they are suffering from "empty nest syndrome," Sabrina suggests they adopt a dog. But when they are turned down by the pound, they are given a trial period as dog owners with Michael, who ends up overstaying his welcome at the Chance's home. Meanwhile, Jimmy tries to prove to Sabrina that he's still a ladies man, even when he doesn't have Hope with him to attract women.
Jimmy and Sabrina get a surprise when they learn that Sabrina's late grandmother has left them the family maid, who has a lifetime contract with the family. Meanwhile, Virginia gets a promotion at work that allows Burt to retire and pursue his passion—even if he doesn't know what his passion is.
In the series finale, Virginia's father Arnold returns to Natesville seeking help in planning his upcoming wedding. But Arnold surprises everyone when he reveals that the wedding Virginia has planned is really for her and Burt—the dream wedding they never got to have as teen parents.